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CB1 Receptor Modulation Against Parkinson's disease in Rats

von Rahul Deshmukh - Verkauft von Dodax EU
Zustand: Neu
€ 54,90
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Rahul Deshmukh CB1 Receptor Modulation Against Parkinson's disease in Rats
Rahul Deshmukh - CB1 Receptor Modulation Against Parkinson's disease in Rats

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Lieferung: zwischen 2021-03-09 und 2021-03-11
Verkauf & Versand: Dodax EU

Beschreibung

Recently, the controversial role of cannabinoid receptors was reported in the pathophysiology of PD. In the present study we have investigated the role of CB1 receptors in motor behaviour. Repeated intranigral (day 1, 7, 14) infusion of MPTP was done to produce stable motor deficits in rats. CB1 receptor agonist, Noladin ether and antagonist AM 251, was administered alone or in combination in MPTP-infused rats. Grip strength, spontaneous locomotor activity and narrow beam walk tests were used to access motor behaviours. Oxidative stress and pro-inflammatory cytokine levels were determined in striatal brain homogenates. MPTP-infused rats showed stable motor deficit and elevation in oxidative stress and cytokine levels. AM 251 attenuated MPYP-induced motor dysfunction, oxidative stress and neuroinflammation in rats. Conversely, noladin ether synergized MPTP- mediated neurotoxicity, which was significantly attenuated by AM 251 pre-treatment. The above results suggests that sustained activation of CB1 receptors may play a crucial role in the development motor dysfunction and thus CB1 receptor blockade would be therapeutic in PD.

Mitwirkende

Autor Rahul Deshmukh

Autor Mayank Prabhakar

Autor Puneet Kumar

Produktdetails

DUIN 18I14CPHF0S

GTIN 9783659645860

Sprache Englisch

Seitenanzahl 108

Produkttyp Taschenbuch

Größe 220 x 150  mm

€ 54,90
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