MOLECULAR MECHANISMS OF HIV-1 LATENCY - Nature and Impact of HIV-1 Integration Sites

von Han, Yefei
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Han, Yefei MOLECULAR MECHANISMS OF HIV-1 LATENCY - Nature and Impact of HIV-1 Integration Sites
Han, Yefei - MOLECULAR MECHANISMS OF HIV-1 LATENCY - Nature and Impact of HIV-1 Integration Sites

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Beschreibung

Advances in the treatment of HIV-1 infection with
highly active anti-retroviral therapy (HAART) have
greatly reduced mortality and changed this fatal
infection into a chronic disease for many. HAART can
reduce viremia to below the clinical limit of
detection. However, eradication of the infection has
not been achieved. HIV-1 can establish latent
infection in a small pool of resting memory T cells
in which the provirus is stably integrated into the
host genome but not producing viral proteins. This
state of latency allows HIV-1 to evade immune
responses and antiretroviral drugs. Upon cellular
activation, replication-competent viruses can be
quickly released from the latent reservoir to
rekindle the infection. Because of its extremely slow
decay rate, the latent reservoir is a major barrier
to curing HIV-1 infection. Dr. Han s dissertation
explored the molecular mechanisms underlying this
unique nature of the infection in resting CD4+ T
cells, starting from the first in vivo analysis of
integration sites in resting CD4+ T cells to the
novel discovery of the bidirectional regulation on
integrated HIV-1 by the host gene transcriptional
read-through.

Mitwirkende

Autor:
Han, Yefei

Weitere Informationen

Biografie:
Dr.Han received her Ph.D. from the Johns Hopkins University
School of Medicine in 2008. Her dissertation research projects on
HIV-1 latency were under the guidance of her thesis advisor,
Dr.Robert Siliciano. She graduated with the Young Investigator
Award and was elected into phi kappa beta. Dr.Han has authored 11
peer reviewed journal articles.
Sprache:
Englisch
Seitenanzahl:
116
Medientyp:
Taschenbuch
Verlag:
VDM Verlag Dr. Müller

Stammdaten

Produkttyp:
Taschenbuch
Verpackungsabmessungen:
0.22 x 0.15 x 0.007 m; 0.222 kg
GTIN:
09783639116380
DUIN:
BBH98LKUKM4
€ 49,00
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